Interstate 80 extends 410 miles from the edge of the great Bonneville Salt Flat at Wendover to the eastern foothills of the Sierra Nevada a few miles west of Verdi. It passes through small towns, small cities and big cities, a route once cursed for its miserable hardships and now so easy that it can be dismissed as boring. Properly experienced, I-80 is a symphony written in mountains, sagebrush and sky and each stop along the way a small adventure.
Interstate 15 is the main route of travel between Los Angeles and Las Vegas, crossing the California line at Primm. In Las Vegas it parallels the Strip for about 3 miles and then swings northeast around the center of the city past North Las Vegas and Nellis Air Force Base. There are turnoffs for Highway 93 north to Caliente and Pioche and east for Lake Mead and the Valley of Fire. At Mesquite it crosses into Utah after traversing 125 miles in Nevada.
US 6 is the real "Loneliest Road", crossing Nevada's empty outback from Montgomery Pass at the California line to Great Basin National Park at the Utah line. In those 297 miles through wide open spaces there are only three towns of more than 100 people, Baker, Ely and Tonopah. Most days you'll have the road to yourself.
US 50 crosses the center of Nevada from Baker and Great Basin National Park on the east 406 miles through Ely, Eureka, Austin, Fallon, Dayton and Carson City to Lake Tahoe on the west.
US 395 is the shortest of Nevada's major highways, extending just 99 miles from Topaz Lake on the south to Bordertown on the north, both at the California state line. On its route along the eastern slope of the Sierra are northern Nevada's largest cities — Minden and Gardnerville, Carson City, Reno and Sparks — and numerous attractions nearby, Genoa, Virginia City, Washoe Lake State Park, and Pyramid Lake among them.
US 95 has the longest run of any major highway in Nevada, totalling 705 miles from the Oregon border at McDermitt to the California line about 20 miles east of Laughlin. It coincides with I-80 for 116 miles west from Winnemucca, and traverses eight counties (nine if you count the 76 miles of 95-A from Schurz to Fernley). Walker Lake sparkles beside it in the summer sun, and side roads lead to hidden treasures like Christmas Tree Pass, Gold Point and Paradise Valley.
The 515 miles along the east side of Nevada from Jackpot in the north to Hoover Dam in the south traverses magnificent landscapes punctuated by flavorful communities: Wells, McGill, Ely, Pioche, Caliente, Alamo, Las Vegas and Boulder City. Side trips abound, from the beautiful Success Summit loop drive to the historic sites of Cherry Creek and the Ward Charcoal Ovens.